ARA-290

Potential Benefits of ARA-290 Peptide

• Neuropathic Symptom Relief: Research suggests ARA 290 has shown promising results in alleviating neuropathic symptoms in patients with type 2 diabetes and sarcoidosis. Both intravenous and subcutaneous administration of this treatment have demonstrated its versatility as a therapeutic agent. [1] [2].
• Metabolic Control: Besides neuropathic symptom relief, ARA 290 also exhibits promising effects on metabolic control in subjects with type 2 diabetes [1]. This dual-action nature may make it an attractive therapeutic option for managing complex, co-morbid conditions.
• Increase in Corneal Nerve Fiber Density: A study demonstrated that ARA 290 can increase corneal nerve fiber density in patients with sarcoidosis-associated small nerve fiber loss [3]. This suggests that ARA 290 has regenerative properties, possibly due to its action on the innate repair receptor.
• Chronic Neuropathic Pain Treatment: ARA 290 acts at the innate repair receptor, a heteromer of the erythropoietin receptor and β-common receptor. This mechanism of action has been associated with the alleviation of chronic neuropathic pain in sarcoidosis patients [4].
• Promising SPECT Tracer for Cardiac Ischemia: ARA-290 peptide has been evaluated for its potential as a Single Photon Emission Computed Tomography (SPECT) tracer for targeting cardiac ischemic regions. The results suggest potential diagnostic benefits [5].
• Treatment of Painful Diabetic Neuropathy: Clinical trials have shown the safety and efficacy of ARA 290 in treating painful diabetic neuropathy [6]. Further larger clinical trials are needed for more conclusive results.
• Potential Neuroprotective Benefits: Apart from its analgesic properties, ARA 290 also appears to have neuroprotective benefits, making it a potential treatment for post-stroke depression [6].
• Attenuating Apoptosis and Inflammation: ARA 290 has been studied for its role in attenuating apoptosis and inflammation in critical limb ischemia, suggesting its potential use in vascular diseases [7] [8].
• Protection against Cytokine-Induced Apoptosis: Research has indicated that ARA 290 can protect rat islets from cytokine-induced apoptosis [8], suggesting possible applications in autoimmune conditions.
• Reducing Tissue Damage: Studies imply that ARA-290 peptide may reduce tissue damage by reducing inflammation [9].

References

[1] https://pubmed.ncbi.nlm.nih.gov/25387363/

[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3563705/

[3] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3883966/

[4] https://www.tandfonline.com/doi/ full/10.1517/21678707.2013.719289

[5] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC8917853/

[6] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC4365069/

[7] https://www.sciencedirect.com/science/ article/pii/S074152141301238X

[8] https://www.researchgate.net/ publication/310146980

[9] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC5741312/

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