Follistatin 344

Potential Benefits of Follistatin 344 Peptide

• Orthopedic Applications: Research suggests Follistatin has shown potential in inhibiting myostatin, a protein that inhibits muscle growth. This property could have significant implications in orthopedics, potentially helping with muscle regeneration and growth [1].
• Treatment of Muscular Dystrophy: Studies have demonstrated that follistatin can potentially increase therapeutic benefits in muscular dystrophy. In one study, an antibody against the HA tag present on the follistatin-344 gene was used as a probe [2]. Another study showed that micro-dystrophin and follistatin co-delivery restored muscle function in an aged DMD model [3].
• Muscle Regeneration: Studies on an engineered follistatin therapeutic showed promise for improving muscle regeneration [4].
• Increasing Lean Muscle Mass: A study involving mice demonstrated that nanoparticle-mediated hepatic delivery of follistatin mRNA resulted in increased lean muscle mass [5].
• Localized hypertrophy of skeletal muscle: Research findings indicate that ACE-083, a follistatin-based ligand trap, has demonstrated functional improvement in neuromuscular disease models through the induction of localized hypertrophy of skeletal muscle [6].
• Becker Muscular Dystrophy Trial: In research, a phase 1/2a follistatin gene therapy trial for Becker muscular dystrophy showed potential benefits [7].

References

[1] https://pubmed.ncbi.nlm.nih.gov/19208403/

[2] https://pubmed.ncbi.nlm.nih.gov/31890729/

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3895965/

[4] https://pubmed.ncbi.nlm.nih.gov/24627466/

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6276093/

[6] https://pubmed.ncbi.nlm.nih.gov/31388039/

[7] https://pubmed.ncbi.nlm.nih.gov/25322757/

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